GNE-477
CAS No. : 1032754-81-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $110 | In-stock |
| 10mg | $184 | In-stock |
| 25mg | $388 | In-stock |
| 50mg | $600 | In-stock |
| 100mg | $910 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-11042 |
| M.Wt: | 504.63 |
| Formula: | C21H28N8O3S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 16.67 mg/mL (ultrasonic) |
GNE-477 is a potent and efficacious dual PI3K (IC50=4 nM)/mTOR(Ki=21 nM) inhibitor.
IC50 & Target: IC50: 4 nM (PI3Kα)[1]
Ki: 21 nM (mTOR)[1]
In Vitro: GNE-477 (Compound 8) has improved potency in the MCF7.1 cell proliferation assay with an EC50 of 143 nM[1].
In Vivo: GNE-477 also exhibits stasis in a PC3 tumor growth inhibition study. In an experiment evaluating the tumor growth inhibition of a PC3 tumor xenograft over 14 days, stasis is achieved at a 20 mg/kg QD dose and significant inhibition is observed with doses as low as 1 mg/kg QD. GNE-477 is generally well tolerated during this study as demonstrated by acceptable levels of weight loss comparable to that observed with the animals in the vehicle cohort[1].
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