MK-2206 dihydrochloride (Standard)
CAS No. : 1032350-13-2
(Synonyms: MK-2206 (2HCl) (Standard))
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| Cat. No. : | HY-10358R |
| M.Wt: | 480.39 |
| Formula: | C25H23Cl2N5O |
| Purity: | >98 % |
| Solubility: |
MK-2206 dihydrochloride (MK-2206 2HCl) (Standard) is the analytical standard of MK-2206 dihydrochloride (HY-10358). This product is intended for research and analytical applications. MK-2206 dihydrochloride is an orally active pan-AKT inhibitor, with IC50 values of 8 nM, 12 nM and 65 nM against AKT1, AKT2 and AKT3, respectively. MK-2206 dihydrochloride inhibits the Akt/mTOR signaling pathway and reduces the levels of downstream GSK3β and Mcl-1 via proteasomal degradation. MK-2206 dihydrochloride induces G1-phase cell cycle arrest, apoptosis, epithelial-mesenchymal transition, fibroblast activation and extracellular matrix deposition. MK-2206 dihydrochloride causes transient hyperglycemia and hyperinsulinemia in animals. MK-2206 dihydrochloride can be used in research related to solid tumors, renal fibrosis and hypercholesterolemia[1][2][3][4].
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Inquiry Information- Product Name:
- MK-2206 dihydrochloride (Standard)
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- HY-10358R
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