ABT-046
CAS No. : 1031336-60-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $220 | In-stock |
| 10mg | $370 | In-stock |
| 50mg | $1400 | In-stock |
| 100mg | $1990 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-15197 |
| M.Wt: | 350.41 |
| Formula: | C20H22N4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 66.67 mg/mL (ultrasonic) |
ABT-046 is a potent, selective, and orally active acyl CoA:diacylglycerol acyltransferase 1 (DGAT-1) inhibitor with IC50s of both 8 nM against human and mouse DGAT-1[1].
IC50 & Target: IC50: 8 nM (hDGAT-1 and mDGAT-1)[1]
In Vitro: ABT-046 shows no inhibition against human DGAT-2 and inhibits triglyceride formation in HeLa cells expressing human DGAT-1 with an IC50 of 78 nM[1].
ABT-046 exhibits high in vitro permeability values in Caco-2 cells with no evidence of active efflux (efflux ratio = 1.4 and 1.1 at 0.5 and 5 μM, respectively)[1].
ABT-046 demonstrates negligible turnover in microsome preparations from mouse and human livers[1].
In Vivo: ABT-046 (0.03-3 mg/kg; i.g.; once) significantly reduced postprandial triglycerides in CD-1 mice[1].
ABT-046 (0.3 mg/kg; i.g.; once) abolishes the postprandial triglyceride excursion in diet-induced obesity mice[1].
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