IMS2186
CAS No. : 1031206-36-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $130 | In-stock |
| 25mg | $275 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-101990 |
| M.Wt: | 296.32 |
| Formula: | C18H16O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 66.67 mg/mL (ultrasonic) |
IMS2186 is an anti-choroidal neovascularization (CNV) agent that inhibits angiogenesis upstream of VEGF. IMS2186 can arrest cancer cell cycle in G2/M phase, thus exerting anti-proliferation and anti-angiogenesis effects. IMS2186 has no intraocular toxicity and reduces the amount of eye leakage and diseased cells[1].
In Vitro:IMS2186 (0.3-10 μM; 22 h) inhibits the proliferation of human fibroblasts and human cancer cells with IC50 values of 1.0-3.0 μM and 0.3-3.0 μM, respectively[1].
IMS2186 (0-10 μM; 22 h) inhibits endodermal tube formation under 10 ng/mL VEGF stimulation with IC50 of 0.1-0.3 μM[1].
IMS2186 (0.1-10 μM; 24 h) inhibits the production of proinflammatory cytokines PGE2/TNF-a in macrophages with IC50 of 0.3-1 μM[1].
IMS2186 (0.1-10 μM; 1.5 h) also inhibits macrophage migration with IC50 of 1 μM[1].
In Vivo:IMS2186 (2.5 mg in 0.5 mL; intravitreal injection; single dose) has no ocular toxicity while applied to rabbit eyes[1].
IMS2186 (100 μg/eye, i.e. 2.0 μL of the solution of 50 μg/μL; single dose) shows anti-proliferative effect on laser-induced choroidal neovascularization (CNV) rat models[1].
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