Bakuchiol

Bakuchiol is a phytoestrogen that can be obtained from psoralen seeds. Bakuchiol has been proven to be a non-competitive inhibitor of multiple enzymes, including UDP-glucuronosyltransferase 2B7 (UGT2B7) ^[2] and human carboxylesterase 2 (hCE2) ^[3], with IC₅₀s values of 40.9 μM and 7.28 μM, respectively. Bakuchiol exhibits significant research and application potential in areas such as anti-inflammatory^[5], antibacterial^[4], antitumor^[1] therapies, as well as drug metabolism regulation. IC50 & Target:IC₅₀:40.9 nM (UGT2B7) ; IC₅₀:7.28 nM (hCE2) In Vitro:Bakuchiol (5-20 μM, 72 h) exhibits selected cytotoxicity in A549 cells, as determined by the MTT assay. Bakuchiol displays stronger effect than its analogue Resveratrol (HY-16561) in reducing the viability of A549 cells with IC₅₀s vales of 9.58 μM and 33.02 μM, respectively^[1].
Bakuchiol (5-20 μM, 24 h or 36h) blocks cell cycle progression at S phase and induction of Reactive Oxygen species (ROS) -related apoptosis (more importantly) in A549 cells in a concentration-dependent manner^[1].
Bakuchiol (0-80 μM, 120 min) is a non-competitive inhibitor of UDP-glucuronosyltransferase 2B7 (UGT2B7) with K_i value of 10.7 μM and IC₅₀ value of 40.9 μM^[2].
Bakuchiol (30 min) is a potent non-competitive inhibitor of human carboxylesterase 2 (hCE2) with low K_i value of 2.12 μM and IC₅₀ value of 7.28 μM^[3].
Bakuchiol (0.9775-3.91 μg/mL, 24 h) demonstrates a significant dose-dependent increase in membrane permeability of the fungal conidia of T. mentagrophytes^[4].
Bakuchiol (3.91 μg/mL, 3 h) elicites a 187% elevation in Reactive Oxygen species (ROS) level in fungal cells^[4].
In Vivo:Bakuchiol (10 and 20 mg/kg, p.o.) can attenuate allergic symptoms, decrease the inflammatory response, improve the T-cell balance, reduce oxidative stress and regulated Igs levels in ovalbumin (OVA) -induced allergic rhinitis (AR) mice^[5].