Phenylthiourea


CAS No. : 103-85-5

(Synonyms: Phenylthiocarbamide)

103-85-5
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Cat. No. : HY-Y0351
M.Wt: 152.22
Formula: C7H8N2S
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 103-85-5 :

Phenylthiourea (Phenylthiocarbamide) is an inhibitor for phenoloxidase. Phenylthiourea inhibits enzymatic oxidation of DOPA by phenoloxidase (Ki = 0.21 μM). Phenylthiourea is an effective inhibitor for tyrosinase. Phenylthiourea can lead to graying of hair in black rats due to the interference with melanin formation[1][2]. IC50 & Target:phenoloxidase[1] In Vitro:Phenylthiourea (Compound PTU) (0-20 μM, 0-300 s) affects the melanization process by either inhibiting the action of phenoloxidase directly or reducing DOPA-quinine to DOPA[1].
Phenylthiourea (0-2.5 μM) has inhibitory effect on DOPA oxidation catalyzed by phenoloxidase (Ki = 0.21 μM)[1].
Phenylthiourea (Compound Phenylthiocarbamide) inhibits the methemoglobin production in rat tissues[2].

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