2-Phenylacetamide

2-Phenylacetamide is a estrogen-like compound that can be isolated from Lepidium apetalum seeds. 2-Phenylacetamide inhibits p38 MAPK signaling pathway, exhibits anti-inflammatory, antioxidant, anti-hypertensive, and anti-fibrosis effects. 2-Phenylacetamide is orally active^[1][2]. In Vitro:2-Phenylacetamide (4-8 μM, 24 h) promotes the proliferation of cancer cell MCF-7, increases expressions of ERα, ERβ and GPR30 in MCF-7^[1].
2-Phenylacetamide (1-10 μM, 6 h) induces ROS generation, inhibits the activation of Renin-angiotensin-aldosterone system (RAAS) system and cytokine release, and reduces the expression of Smad3 and TGF-β in high NaCl-stimulated NRK52e cells^[2].
In Vivo:2-Phenylacetamide (25-50 mg/kg, po, 7 days) increases the uterine coefficient, luteinizing hormone (LH) and estrogen (E2) levels in immature mice^[1].
2-Phenylacetamide (15-45 mg/kg, po, once daily for 4 weeks) improves kidney damage caused by hypertension, lowers blood pressure, and reduces kidney pathological damage and collagen deposition in rats spontaneously hypertensive models^[2].