Ethyl cinnamate

Ethyl cinnamate, an orally active chemical constituent of the rhizome of Kaempferia galanga, exhibits anti-cancer, nematocidal, sedative and vasorelaxant activities. Ethyl cinnamate is a fragrance ingredient used as a food flavor and additive for cosmetic products. Ethyl cinnamate is also an excellent clearing reagent for mammalian tissues. Ethyl cinnamate suppresses tumor growth through anti-angiogenesis by attenuating VEGFR2 signal pathway in colorectal cancer. Ethyl cinnamate inhibits the tonic contractions induced by high K+ and phenylephrine (PE) with respective IC₅₀ values of 0.30 mM and 0.38 mM in rat aorta^[1][2][3][4]. In Vitro:Ethyl cinnamate (0-80 μM, 24 h and 48 h) inhibits VEGF-induced viability, motility, tube formation of Human umbilical vein endothelial cells (HUVECs) in a VEGFR2-dependent manner and induces HUVECs apoptosis^[3].
In Vivo:Ethyl cinnamate (1-4 μM, incubation, a single dose) inhibits blood vessel formation in zebrafish embryos^[3].
Ethyl cinnamate (15, 30, 60 mg/kg, p.o., daily for 21 days) suppresses tumor growth and angiogenesis of HT29 nude mouse colon cancer xenograft model^[3].