PF-4191834
CAS No. : 1029317-21-2
(Synonyms: PF-04191834)
| Size | Price | Stock |
|---|---|---|
| 5mg | $66 | In-stock |
| 10mg | $105 | In-stock |
| 25mg | $210 | In-stock |
| 50mg | $330 | In-stock |
| 100mg | $475 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-117048 |
| M.Wt: | 393.50 |
| Formula: | C22H23N3O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
PF-4191834 (PF-04191834) is an orally active, noniron chelating, and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) (IC50=229 nM), displays ~300-fold selectivity for 5-LOX over 12-LOX and 15-LOX, shows no activity toward the cyclooxygenase enzymes, and is effective in inflammation and pain[1].
IC50 & Target: IC50: 229 nM (5-LOX), 130 nM (human 5-LOX)[1]
In Vitro: PF-4191834 (PF-04191834) inhibits the synthesis of the 5-LOX products 5-HETE, 5-oxo-ETE, LTB4, and LTE4 with estimated IC50 values between 100 and 190 nM and do not inhibit significantly the COX-1/2 enzymes or the 12- or 15-LOX enzymes at concentrations up to 30 μM[1].
PF-4191834 (PF-04191834) exerts a concentration-dependent inhibition of human 5-LOX, with an IC50 value of 130 nM and an IC80 value of 370 nM[1].
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