τ-Fluvalinate
CAS No. : 102851-06-9
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| Cat. No. : | HY-B2021 |
| M.Wt: | 502.91 |
| Formula: | C26H22ClF3N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL |
τ-Fluvalinate is an insecticide and in-hive miticide, with its mechanism involving interfering with nervous systems. τ-Fluvalinate binds to the open state of Varroa destructor (VdNaV1) and Apis mellifera (AmNaV1) voltage-dependent sodium channels, with EC50 values of 160 nM and 60 nM respectively. τ-Fluvalinate has higher affinity for AmNaV1, which causes sublethal toxicity to honeybees. τ-Fluvalinate can be applied for research on Varroa destructor infestation in honeybee colonies[1][2]. In Vitro:τ-Fluvalinate (1 nM-10 μM) modifies heterologously expressed AmNaV1 channels with higher affinity (EC50 = 60 nM) and greater maximal effect than VdNaV1 channels (EC50 = 160 nM) in Xenopus laevis oocytes[2].
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