PHOME
CAS No. : 1028430-42-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $85 | In-stock |
| 5mg | $300 | In-stock |
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| 50 mg | Get quote | |
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| Cat. No. : | HY-113862 |
| M.Wt: | 373.40 |
| Formula: | C23H19NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic);DMSO : ≥ 10 mg/mL |
PHOME is a fluorogenic substrate for sEH. sEH can hydrolyze the epoxy ring in the PHOME substrate. PHOME can be used for fluorescent epoxide hydrolase assay[1].
In Vitro:PHOME enters the sEH active site and is hydrolyzed by sEH to generate the fluorescent product 6-methoxy-2-naphthaldhyde. The fluorescence intensity of 6-methoxy-2-naphthaldhyde can be detected by a fluorescence detector to evaluate the activity of sEH or the efficacy of sEH inhibitors[2].
PHOME can be used to develop the liquid chromatography-biochemical detection (LC-BCD) system for efficient screening and quantitative analysis of sEH inhibitors[2].
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