Levetiracetam
CAS No. : 102767-28-2
(Synonyms: UCB L059)
| Size | Price | Stock |
|---|---|---|
| 50mg | $79 | In-stock |
| 100mg | $132 | In-stock |
| 500mg | $343 | In-stock |
| 1 g | Get quote | |
| 5 g | Get quote | |
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| Cat. No. : | HY-B0106 |
| M.Wt: | 170.21 |
| Formula: | C8H14N2O2 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 85 mg/mL;DMSO : ≥ 85 mg/mL |
Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent[1][2].
IC50 & Target:M2 mAChR[1]
In Vitro: Levetiracetam increases the transcription of HDACs and recruits corepressor complex on O6-Methylguanine-DNA-methyltransferase (MGMT) promoter, thus silencing its activity[1].
Levetiracetam sensitizes (40 μg/mL) glioblastoma multiforme stem-like cells (GSCs) to Temozolomide (250 μM) treatment[1].
MGMT expression is downregulated in GCSCs treated with Levetiracetam (40 μg/mL)[1]
In Vivo: Levetiracetam (10, 25, or 50 mg/kg) suppresses behavioral and electrographic seizure activity during neonatal hypoxia[2].
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