DUPA(OtBu)-OH
CAS No. : 1026987-94-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $64 | In-stock |
| 10mg | $96 | In-stock |
| 25mg | $164 | In-stock |
| 50mg | $225 | In-stock |
| 100mg | $315 | In-stock |
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| Cat. No. : | HY-103591 |
| M.Wt: | 488.57 |
| Formula: | C23H40N2O9 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
DUPA(OtBu)-OH is a DUPA precursor. DUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer. In Vitro: DUPA(OtBu)-OH (DUPA precursor 17) is a 2-[3-(1,3-dicarboxypropyl)ureido]pentanedioic acid (DUPA) reagent[1]. The targeting ligand DUPA enhances the transport capability and selectivity of Paclitaxel (PTX) to tumor cells via prostate-specific membrane antigen (PSMA) mediated endocytosis. Besides, DUPA is conjugated with PTX via a disulfide bond, which facilitates the rapid and differential drug release in tumor cells[2]. In Vivo: DUPA-targeted Docetaxel (DTX) conjugate with longer spacer has no toxicity in major organs of treated mice[3].
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