Dexfadrostat
CAS No. : 102676-87-9
(Synonyms: (R)-Fadrozole; (R)-CGS 16949A (free base); FAD286)
| Size | Price | Stock |
|---|---|---|
| 1mg | $180 | In-stock |
| 5mg | $400 | In-stock |
| 10mg | $620 | In-stock |
| 25mg | $1240 | In-stock |
| 50mg | $1920 | In-stock |
| 100mg | $2880 | In-stock |
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| Cat. No. : | HY-113986 |
| M.Wt: | 223.27 |
| Formula: | C14H13N3 |
| Purity: | >98 % |
| Solubility: | DMSO : 110 mg/mL (ultrasonic) |
Dexfadrostat ((R)-Fadrozole) is a potent nonsteroidal inhibitor[1]. Dexfadrostat also inhibits human placental aromatase (pIC50 = 6.17) and aldosterone biosynthesis. Dexfadrostat reverses cardiac fibrosis in spontaneously hypertensive heart failure rats.[1][2].
IC50 & Target:pIC50: 6.17 (human placental aromatase)
In Vitro:The (-)-enantiomer with the S-absolute configuration was responsible for the high aromatase inhibitory activity of Dexfadrostat[1].
In Vivo:Dexfadrostat ((R)-fadrozole; 0.24 and 1.2 mg/kg; daily; oral) and (S)-fadrozole similarly decreases plasma aldosterone levels, whereas urinary aldosterone excretion rate was reduced only by S-fadrozole[2].
Dexfadrostat (0.24 and 1.2 mg/kg; daily; oral) effectively reverses preexistent left ventricular interstitial fibrosis by 50% (vs. 42% for canrenoate), S-fadrozole was devoid of an antifibrotic effect[2].
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