Dexfadrostat
CAS No. : 102676-87-9
(Synonyms: (R)-Fadrozole; (R)-CGS 16949A (free base); FAD286)
| Size | Price | Stock |
|---|---|---|
| 1mg | $180 | In-stock |
| 5mg | $400 | In-stock |
| 10mg | $620 | In-stock |
| 25mg | $1240 | In-stock |
| 50mg | $1920 | In-stock |
| 100mg | $2880 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-113986 |
| M.Wt: | 223.27 |
| Formula: | C14H13N3 |
| Purity: | >98 % |
| Solubility: | DMSO : 110 mg/mL (ultrasonic) |
Dexfadrostat ((R)-Fadrozole) is an orally active and selective aromatase inhibitor, with human aromatase IC50 values of 6.4 nM. Dexfadrostat suppresses estrogen synthesis, reduces circulating estradiol levels and suppresses aldosterone production. Dexfadrostat can be used for the research of breast cancer, primary aldosteronism, and hypertension[1][2][3][4].
IC50 & Target:pIC50: 6.17 (human placental aromatase)
In Vitro:Dexfadrostat (20 min) potently inhibits human placental aromatase in vitro with an IC50 of 6.4 nM[1].
Dexfadrostat potently inhibits rat ovarian aromatase in vitro[1].
In Vivo:Dexfadrostat (Compound 26a) (p.o.; single dose) potently inhibits androstenedione-induced uterine hypertrophy in immature female rats with an oral ED50 of 0.03 mg/kg[1].
Dexfadrostat (p.o.) reduces circulating estradiol levels and suppresses uterine weight in intact cyclic female rats without inducing adrenal hypertrophy at doses that maximally inhibit estrogen synthesis[1].
Dexfadrostat (p.o.; daily) exhibits potent antitumor efficacy in intact female rats with DMBA (HY-W011845)-induced mammary tumors[1].
Dexfadrostat (0.01 μmol/kg; p.o.; single dose) significantly inhibits ovarian estrogen synthesis in female rats[1].
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