Maprotiline
CAS No. : 10262-69-8
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| Cat. No. : | HY-B0444A |
| M.Wt: | 277.40 |
| Formula: | C20H23N |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Maprotiline is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects. Maprotiline induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1[1][2].
In Vitro:Maprotiline (0-20 μM, 0-72 h) inhibits the growth of Huh7 and HepG2 cells and induces cell apoptosis[1].
Maprotiline (0-20 μM, 0-72 h) inhibits the metastasis of liver cancer cells[1].
Maprotiline (0-20 μM, 72 h) affects the ERK pathway and inhibits the phosphorylation of SREBP2 in HepG2 and Huh7 cells[1].
Maprotiline targets CRABP1 and regulates cholesterol biosynthesis in HCC cells[1].
In Vivo:Maprotiline (20-40 mg/kg, intraperitoneal injection, twice a week for three weeks) inhibits liver cancer tumor growth in mice[1].
Maprotiline (3-30 mg/kg, intravenous injection, single dose) combined with the synthetic cannabinoid WIN 55,212-2 effectively reduces neuropathic pain in mice[2].
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