GSK-626616
CAS No. : 1025821-33-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $57 | In-stock |
| 5mg | $95 | In-stock |
| 10mg | $170 | In-stock |
| 25mg | $380 | In-stock |
| 50mg | $660 | In-stock |
| 100mg | $1050 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-105309 |
| M.Wt: | 401.27 |
| Formula: | C18H10Cl2N4OS |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
GSK-626616 is a potent, orally bioavailable inhibitor of DYRK3 (IC50=0.7 nM). GSK-626616 inhibits other members of the DYRK family (e.g., DYRK1A and DYRK2) with similar potency, which is a potential therapy for the treatment of anemia[1].
IC50 & Target: IC50: 0.7 nM (DYRK3)[1]
In Vitro: GSK-626616 abolishes the phosphorylation of S6K1 at Thr389 in nonstimulated HeLa cells. GSK-626616 reduces the phosphorylation of S6K1 at Thr389 in EGF- and insulin-stimulated HeLa cells, showing that mTORC1 activity is impaired[2].
GSK-626616 (serum-deprived HeLa cells) reduces EGF-induced phosphorylation of PRAS40 at Thr246. Binding of PRAS40 to mTORC1 is enhanced by GSK-626616[2].
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