Resolvin D4
CAS No. : 1025684-60-9
(Synonyms: RvD4)
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| Cat. No. : | HY-113533 |
| M.Wt: | 376.49 |
| Formula: | C22H32O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Resolvin D4 (RvD4), a specialized proresolving mediator, can be produced in bioactive levels during S. aureus infection[1].
In Vitro:Resolvin D4 (RvD4) stops neutrophil infiltration in sterile peritonitis and S. aureus skin infection[1].
Resolvin D4 (RvD4, 0-10 nM) enhances human macrophage and dermal fibroblast phagocytosis and efferocytosis[1].
Resolvin D4 (RvD4, 0-10 nM) statistically significantly increases macrophage efferocytosis of apoptotic neutrophils by 40-50%[1].
In Vivo:Resolvin D4 (RvD4, 10 ng/mouse) decreases percent of PMN, giving ~31% reduction at 4 hours[1].
Resolvin D4 (RvD4, 10 ng/mouse) modulates the severity of thrombo-inflammatory disease in vivo and improves thrombus resolution[2].
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