LM11A-31
CAS No. : 102562-74-3
| Size | Price | Stock |
|---|---|---|
| 1g | $120 | In-stock |
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| Cat. No. : | HY-117088 |
| M.Wt: | 243.35 |
| Formula: | C12H25N3O2 |
| Purity: | >98 % |
| Solubility: |
LM11A-31, a non-peptide p75NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist. LM11A-31 is an amino acid derivative with high blood-brain barrier permeability and blocks p75-mediated cell death. LM11A-31 reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression[1][2].
In Vivo:LM11A-31 (oral gavage; 50 mg kg/day for 4 weeks) significantly mitigates proNGF accumulation and preserves BRB integrity[1].
LM11A-31 (orally; 50 or 75 mg/kg) administered for 3 months starting at 6-8 months of age prevents and/or reverses atrophy of basal forebrain cholinergic neurites and cortical dystrophic neurites in mid-stage male APPL/S mice[2].
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