Olaratumab
CAS No. : 1024603-93-7
(Synonyms: IMC-3G3; LY3012207)
| Size | Price | Stock |
|---|---|---|
| 1mg | $300 | In-stock |
| 5mg | $780 | In-stock |
| 10mg | $1250 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-P9922 |
| M.Wt: | 1000.00 |
| Formula: | N/A |
| Purity: | >98 % |
| Solubility: | H2O |
Olaratumab (IMC-3G3; LY3012207) is an anti-platelet-derived growth factor receptor alpha (PDGFRα) human monoclonal IgG1 antibody with antitumor activity[1].
IC50 & Target:PDGFRA/CD140a
In Vitro: IMC-3G3 (100 μg/mL, 72 h) blocked PDGFRα phosphorylation in SKOV3-ip1 cells. And the combined treatment of IMC-3G3 and docetaxel significantly induced apoptosis in SKOV3-ip1 and HeyA8 cell lines[1].
In Vivo: IMC-3G3 (i.p., 40 mg/kg, three times per week, 6 weeks) in SKOV3-ip1 tumor-bearing mice, compared with the control group, IMC-3G3 treatment alone had no obvious anti-tumor effect, while in HeyA8 tumor-bearing mice, IMC-3G3 monotherapy showed a significant anti-tumor effect compared with the control group, with a tumor reduction rate of 62%[1].
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