Pentabromopseudilin
CAS No. : 10245-81-5
| Size | Price | Stock |
|---|---|---|
| 1mg | $260 | In-stock |
| 5mg | $780 | In-stock |
| 10mg | $1250 | In-stock |
| 25mg | $2400 | In-stock |
| 50mg | $3850 | In-stock |
| 100mg | $6150 | In-stock |
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| Cat. No. : | HY-113604 |
| M.Wt: | 553.66 |
| Formula: | C10H4Br5NO |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Pentabromopseudilin (PBrP) is a marine antibiotic isolated from the marine bacteria Pseudomonas bromoutilis and Alteromonas luteoviolaceus. PBrP exhibits antimicrobial, anti-tumour and phytotoxic activities. PBrP is a reversible and allosteric inhibitor of myosin Va (MyoVa). PBrP also is a potent inhibitor of transforming growth factor-β (TGF-β) activity. PBrP can be used for the research of fibrotic diseases and cancer[1].
In Vitro:Pentabromopseudilin (PBrP) (0.01-1 μM, 6 h) prevents TGF-β-induced Smad protein phosphorylation and nuclear translocation[1].
PBrP (0.5 μM, 6 h) inhibits TGF-β-stimulated transcriptional responses[1].
PBrP (0-1 μM, 6 h) inhibits TGF-β-induced EMT in A549 cells[1].
PBrP (0.2 μM, 20 h) suppresses TGF-β-induced cell migration[1].
PBrP (0.01-1 μM, 6 h) blocks TGF-β signalling by enhancing degradation of TβRII[1].
PBrP (0.5 μM, 0, 1, 3 h) blocks TGF-β signalling by enhancing degradation of TβRII via caveolae[1].
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