PF-3882845
CAS No. : 1023650-66-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $112 | In-stock |
| 5mg | $283 | In-stock |
| 10mg | $395 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-12738 |
| M.Wt: | 419.90 |
| Formula: | C24H22ClN3O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic;warming) |
PF-3882845 is a remarkably high affinity selective and orally efficacious mineralocorticoid receptor (MR binding IC50=2.7 nM) antagonist for hypertension and nephropathy. PF-3882845 also binds to progesterone receptor (PR) with the binding IC50 of 310 nM[1].
IC50 & Target:IC50: 2.7 nM (mineralocorticoid receptor), 310 nM (progesterone receptor)[1]
In Vivo:PF-3882845 (10-100 mg/kg; Orally via gavage; twice a day; for 21 days) reduces blood pressure, decreases urinary albumin, and protects kidney in Dahl SS rat[1].
PF-3882845 exhibits moderate oral bioavailability (F = 86%) following oral administration (2 mg/kg) in male Sprague-Dawley rats[1].
PF-3882845 exhibits terminal elimination half-lives (T1/2 1.7 h) due to high plasma clearance (CL 9.8 mL/min/kg) combined with large volumes of distribution (Vdss 1.4 mL/kg respectively) following intravenous administration (2 mg/kg) in male Sprague-Dawley rats[1].
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- PF-3882845
- Cat. No.:
- HY-12738
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