(E)-KME-4
CAS No. : 102271-49-8
(Synonyms: PGS-IN-1)
| Size | Price | Stock |
|---|---|---|
| 5mg | $125 | In-stock |
| 10mg | $220 | In-stock |
| 25mg | $470 | In-stock |
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| Cat. No. : | HY-101587 |
| M.Wt: | 302.41 |
| Formula: | C19H26O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
(E)-KME-4 is a potent inhibitor of prostaglandin synthetase (PGS) with an IC50 of 0.28 μM; also inhibits 5-lipoxygenase with an IC50 of 1.05 μM. IC50 & Target:IC50: 0.28 μM (PGS), 1.05 μM (5-lipoxygenase)[1] In Vitro: The synthesized α-benzulidene-γ-butyrolactones are pure isomers (either cis or trans). (E)-KME-4 is the trans isomer. PGS-IN-1 exhibits potent antiinflammatrory and PGS inhibitory activity (IC50=0.28 μM). (E)-KME-4 also shows potent inhibitory activity against 5-lipoxygenase (IC50=1.05 μM)[1].
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