TT01001


CAS No. : 1022367-69-6

1022367-69-6
Price and Availability of CAS No. : 1022367-69-6
Size Price Stock
5mg $125 In-stock
10mg $200 In-stock
25mg $400 In-stock
50mg $640 In-stock
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Cat. No. : HY-114520
M.Wt: 376.30
Formula: C15H19Cl2N3O2S
Purity: >98 %
Solubility: DMSO : 125 mg/mL (ultrasonic)
Introduction of 1022367-69-6 :

TT01001 is a selective and orally active mitoNEET agonist and a monoamine oxidase B (MAO-B) inhibitor (IC50 = 8.84 μM). TT01001 does not activate PPARγ but interacts with MitoNEET. TT01001 attenuates oxidative stress and neuronal apoptosis by preventing mitoNEET-mediated mitochondrial dysfunction. TT01001 improves type II diabetes and ameliorates mitochondrial function of mice. TT01001 can used for the studies of type II diabetes and neurological disorders [1][2][3]. In Vivo:TT01001 (100 mg/kg, p.o., once daily for 28 days) improves type II diabetes without causing weight gain and ameliorates mitochondrial function of db/db mice[1].
TT01001 (1-9 mg/kg, i.p., single dose) attenuates oxidative stress and neuronal apoptosis by preventing mitoNEET-mediated mitochondrial dysfunction after subarachnoid hemorrhage (SAH) in rats[2].

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