| Size | Price | Stock |
|---|---|---|
| 5mg | $125 | In-stock |
| 10mg | $200 | In-stock |
| 25mg | $400 | In-stock |
| 50mg | $640 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
| We match the lowest price on market. | ||
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| Cat. No. : | HY-114520 |
| M.Wt: | 376.30 |
| Formula: | C15H19Cl2N3O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
TT01001 is a selective and orally active mitoNEET agonist and a monoamine oxidase B (MAO-B) inhibitor (IC50 = 8.84 μM). TT01001 does not activate PPARγ but interacts with MitoNEET. TT01001 attenuates oxidative stress and neuronal apoptosis by preventing mitoNEET-mediated mitochondrial dysfunction. TT01001 improves type II diabetes and ameliorates mitochondrial function of mice. TT01001 can used for the studies of type II diabetes and neurological disorders [1][2][3].
In Vivo:TT01001 (100 mg/kg, p.o., once daily for 28 days) improves type II diabetes without causing weight gain and ameliorates mitochondrial function of db/db mice[1].
TT01001 (1-9 mg/kg, i.p., single dose) attenuates oxidative stress and neuronal apoptosis by preventing mitoNEET-mediated mitochondrial dysfunction after subarachnoid hemorrhage (SAH) in rats[2].
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