N-Boc-4-hydroxy-L-proline methyl ester
CAS No. : 102195-79-9
| Size | Price | Stock |
|---|---|---|
| 5g | $10 | In-stock |
| 10g | $14 | In-stock |
| 25g | $18 | In-stock |
| 50g | $35 | In-stock |
| 100g | $66 | In-stock |
| 500g | $329 | In-stock |
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| Cat. No. : | HY-Y0755 |
| M.Wt: | 245.27 |
| Formula: | C11H19NO5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
N-Boc-cis-4-hydroxy-L-proline methyl ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-L-proline methyl ester is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2
In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
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