sst2 Receptor agonist-1
CAS No. : 1021912-42-4
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| Cat. No. : | HY-110161 |
| M.Wt: | 432.94 |
| Formula: | C26H25ClN2O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
sst2 Receptor agonist-1 is a potent somatostatin receptor subtype 2 (sst2) agonist with a Ki value of 0.025 nM and a cAMP IC50 value of 4.8 nM. sst2 Receptor agonist-1 can?inhibit rat growth hormone (GH) secretion and ocular neovascular lesion formation. Antiangiogenic effect[1].
In Vivo: sst2 Receptor agonist-1 (compound 21) (0.2 or 2 mg/kg; IV; single dosage) shows a dose-dependent decrease in growth hormone (GH) secretion[1].
sst2 Receptor agonist-1 (5 or 15 μg/per eye; intraocular; once every 4 days) reduces neovascular lesion area in laser choroidal neovascularization (CNV) rat model[1].
Pharmacokinetic Parameters of sst2 Receptor agonist-1 (compound 21) in dogs and rats[1].
| species | dog (IV 0.125 mg/kg) | rat (IV 2 mg/kg or 5 mg/kg) |
| CLplasma (mL/min/kg) | 7.1 | 52 |
| t1/2 (h) | 11 | 2.9 |
| VdSS (L/kg) | 5.7 | 9.4 |
| F (%) | ND | 17 |
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