PPNDS (tetrasodium)
CAS No. : 1021868-77-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $110 | In-stock |
| 5mg | $330 | In-stock |
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| Cat. No. : | HY-108675 |
| M.Wt: | 694.36 |
| Formula: | C18H11N4Na4O14PS2 |
| Purity: | >98 % |
| Solubility: | H2O : 37.5 mg/mL (ultrasonic;warming;heat to 60°C) |
PPNDS tetrasodium is a selective and competitive meprin β inhibitor (IC50: 80 nM, Ki: 8 nM), and also inhibits ADAM10 (IC50: 1.2 μM). PPNDS tetrasodium is also a P2X1 receptor antagonist. PPNDS is an agonist for the ATP receptor of Paramecium. PPNDS tetrasodium potently inhibits polymerases from viruses. PPNDS tetrasodium can be used in the research of infection and cancers[1][3][4].
IC50 & Target: IC50: 80 nM (meprin β), 67 μM (meprin α)[1].
In Vitro: PPNDS tetrasodium inhibits meprin β (IC50: 80 nM) and meprin α (67 μM)[1].
PPNDS tetrasodium (0-10 μM, 15 min) inhibits mNV-RdRp (murine Norovirus RNA-dependent RNA-polymerase) with an IC50 value of 0.88 μM[2].
PPNDS tetrasodium (0.025-10 µM) potently inhibits polymerases from six viruses spanning the three Caliciviridae genera tested (IC50 range: 0.1-2.3 μM)[4].
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