C1A
CAS No. : 1021463-02-4
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| Cat. No. : | HY-124946 |
| M.Wt: | 498.42 |
| Formula: | C22H25Cl2N3O4S |
| Purity: | >98 % |
| Solubility: |
C1A is a class I/II HDACs and sirtuin inhibitor with an IC50 of 479 nM for HDAC6. C1A induces sustained acetylation of HDAC6 substrates, α-tubulin and HSP90. C1A shows srtong anticancer effcts, and induces apoptosis in cancer cells[1].
In Vitro:C1A (2.5-10 μM; 24 h) increases the sub-G1 population in a drug concentration-related manner. And C1A induces apoptosis and inhibits proliferation of a panel of human tumour cell lines from different origins in the low micromolar range[1].
In Vivo:C1A (20-40 mg/kg; ip; once a day, twice a day, once every two days; for 14 days) inhibits the growth of colon tumours in vivo[1].
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