Pseudoprotodioscin
CAS No. : 102115-79-7
| Size | Price | Stock |
|---|---|---|
| 1mg | $30 | In-stock |
| 5mg | $70 | In-stock |
| 10mg | $115 | In-stock |
| 20mg | $180 | In-stock |
| 50mg | $360 | In-stock |
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| Cat. No. : | HY-N0686 |
| M.Wt: | 1031.18 |
| Formula: | C51H82O21 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : ≥ 100 mg/mL |
Pseudoprotodioscin, a furostanoside, inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides[1]. In Vitro: In Hep G2 cells, Pseudoprotodioscin increases ABCA1 protein and mRNA levels, and promotes the effluxion of ApoA-1-mediated cholesterol. Pseudoprotodioscin inhibits SREBP1c and SREBP2 transcription by decreasing microRNA 33a/b levels. This procedure reciprocally lead to the increase of ABCA1 levels. In THP-1 macrophages, Pseudoprotodioscin shows the similar effect, which reduces HMGCR, FAS and ACC mRNA levels and promotes low density lipoprotein receptor by decreasing the PCSK9 levels[1].
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