Gardiquimod
CAS No. : 1020412-43-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $80 | In-stock |
| 25mg | $180 | In-stock |
| 50mg | $280 | In-stock |
| 100mg | $480 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-103697 |
| M.Wt: | 313.40 |
| Formula: | C17H23N5O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 20 mg/mL;Ethanol : ≥ 12 mg/mL;DMF : ≥ 20 mg/mL |
Gardiquimod, an imidazoquinoline analog, is a TLR7/8 agonist. Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells (PBMCs). Gardiquimod specifically activates TLR7 when used at concentrations below 10 μM[1][2]. IC50 & Target: TLR7, HIV-1 reverse transcriptase[1] In Vitro: Gardiquimod (6-60 μM ) significantly inhibits cDNA synthesis by HIV-1 reverse transcriptase[1]. In Vivo: Dendritic cells (DCs) in combination with Gardiquimod (1 mg/kg per mouse; i.p.; daily for 7 days) improves the anti-tumor effects of NK cells[2].
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