Meayamycin B
CAS No. : 1020210-12-1
(Synonyms: (+)-Meayamycin B)
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| Cat. No. : | HY-15867 |
| M.Wt: | 576.72 |
| Formula: | C31H48N2O8 |
| Purity: | >98 % |
| Solubility: |
Meayamycin B ((+)-Meayamycin B) is a potent SF3B1 inhibitor. Meayamycin B upregulates the proapoptotic Mcl-1S and downregulates Mcl-1L at the pre-mRNA splicing level. Meayamycin B does not regulate the alternative splicing of Bcl-x. Meayamycin B and ABT-737 (HY-50907) synergistically causes Apoptosis. Meayamycin B exhibits anticancer activity against non-small cell lung cancer[1].
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