YM-359445 (dihydroxybutanedioate)
CAS No. : 1020067-28-0
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| Cat. No. : | HY-117039 |
| M.Wt: | 662.71 |
| Formula: | C32H34N6O8S |
| Purity: | >98 % |
| Solubility: |
YM-359445 dihydroxybutanedioate is an orally active VEGFR2 tyrosine kinase inhibitor, with an IC50 of 8.5 nM. YM-359445 dihydroxybutanedioate shows a complete inhibition of vascular permeability induced by VEGF. YM-359445 dihydroxybutanedioate shows antitumor activity against both lung cancer and Paclitaxel (HY-B0015)-resistant colon cancer[1].
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