Sulfaclozine

Sulfaclozine (Sulfachloropyrazine) is an efficacious sulphonamide derivative with antibacterial and anticoccidial effects. Sulfaclozine is commonly used for the treatment of various poultry diseases (particularly, collibacteriosis, fowl cholera and coccidiosis)^[1]. IC50 & Target:Bacterial; Parasite^[1] In Vitro: The elimination of Sulfaclozine in the three systems: UV/TiO₂, UV/K₂S₂O₈, and UV/TiO₂/K₂S₂O₈. Sulfaclozine is weakly adsorbed on the surface of TiO₂ at pH 7 (< 5%) but efficiently eliminated with the following three systems: UV/TiO₂, UV/K₂S₂O₈, and UV/TiO₂/K₂S₂O₈ in ultra pure water. Moreover, 12 of Sulfaclozine by-products are identified and reaction pathways show that, in addition of ^?OH and SO₄^?? radicals, the conduction-band electrons are responsible for the formation of some main by-products either directly or by the formation of superoxide radicals^[2]. In Vivo: Sulfaclozine (60 mg/kg; intravenous injection or oral administration; male broiler chickens) can be used primarily for the treatment of parasitic and microbial infections of the digestive tract rather than for the treatment of systemic infections^[1].