1,3-Diphenylguanidine

1,3-Diphenylguanidine is a widely used accelerator in rubber vulcanization. 1,3-Diphenylguanidine increases ROS activity and decreases SOD and CAT activity. 1,3-Diphenylguanidine accelerates the vulcanization process. 1,3-Diphenylguanidine impairs the reproduction and growth of Moina macrocopa^{[1] [2] [3] . In Vitro:1,3-Diphenylguanidine (0.5 mg/L) increases ROS activity, decreases activities of SOD and CAT in Moina macrocopa, along with impaired reproduction and growth[2]. In Vivo:1,3-Diphenylguanidine (0.06-16 mg/kg; p.o.; daily; 8 weeks) has no significant adverse effects on body weight gain, organ weights, testis histology, male fertility, or embryonic/fetal development in male CD-1 mice, except for a slight increase in sperm with folded tails but normal heads at 16 mg/kg[3].}