GW791343 (dihydrochloride)
CAS No. : 1019779-04-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $84 | In-stock |
| 10mg | $144 | In-stock |
| 50mg | $456 | In-stock |
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| Cat. No. : | HY-15469 |
| M.Wt: | 447.35 |
| Formula: | C20H26Cl2F2N4O |
| Purity: | >98 % |
| Solubility: | DMSO : 20 mg/mL (ultrasonic);H2O : 100 mg/mL (ultrasonic) |
GW791343 dihydrochloride is a potent human P2X7 receptor negative allosteric modulator (exhibits species-specific activity), produces a non-competitive antagonist effect on human P2X7 receptor, with a pIC50 of 6.9-7.2. GW791343 dihydrochloride can enhance ATP rhythm. GW791343 dihydrochloride can be used in study of neurological disease[1][2].
In Vitro: GW791343 dihydrochloride (0.01, 0.03, 0.1, 0.3, 1, 3, 10 µM; 40 min) shows a non-competitive antagonistic activity to the human P2X7 receptor[1].
GW791343 dihydrochloride (3, 10, 30 µM; 40 min) shows an anegative allosteric modulate activity to the human P2X7 receptor[1].
GW791343 dihydrochloride (5 µM; 24-48 h; ATP measured every 4 h) enhances ATP rhythm in SCN cells[2].
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