REV 5901
CAS No. : 101910-24-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $74 | In-stock |
| 10mg | $120 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-112532 |
| M.Wt: | 335.44 |
| Formula: | C22H25NO2 |
| Purity: | >98 % |
| Solubility: |
REV 5901 is a competitive and orally active antagonist of leukotriene receptor, with a Ki of 0.7 μM. REV 5901 is also a 5-lipoxygenase inhibitor. REV 5901 can be used for the research of asthma in which leukotriene release be involved. REV 5901 can be used for the study of colon carcinoma[1][2][3].
IC50 & Target:Ki: 0.7 μM (leukotriene receptor)[1]
[2]
In Vitro:REV 5901 (24 h) inhibits cell viability of CT26CL25 cells with an IC50 of 30 μM[3].
In Vivo:In guinea-pig, REV 5901 (10-30 mg/kg, i.v.) substantially inhibits the bronchoconstriction, measured as changes in airways resistance (RL) and dynamic lung compliance (Cdyn), induced by leukotriene D4 (2.5 μg/kg, i.v.)2.
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