| Size | Price | Stock |
|---|---|---|
| 1mg | $550 | In-stock |
| 5mg | $1450 | In-stock |
| 10 mg | Get quote | |
| 50 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
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Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-114519 |
| M.Wt: | 304.34 |
| Formula: | C17H20O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Helenalin acetate, a natural NF-κB inhibitor, is a potent C/EBPβ inhibitor. Helenalin acetate has anti-inflammatory and anticancer activities[1].
In Vitro:Helenalin acetate (0.1-1 μM; for 7 days) inhibits the differentiation significantly in 3T3-L1 cells[1].
Helenalin acetate exerts anti-proliferative effects in acute myeloid leukemia cells but not in normal hematopoietic progenitor cells[1].
Helenalin acetate inhibits C/EBPβ by binding to the N-terminal part of C/EBPβ, thereby disrupting the cooperation of C/EBPβ with the co-activator p300. Helenalin acetate selectively inhibits only the full-length (liver-enriched activating protein* (LAP*)) isoform but not the slightly shorter (LAP) isoform[1].
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