Helenalin acetate


CAS No. : 10180-86-6

10180-86-6
Price and Availability of CAS No. : 10180-86-6
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Cat. No. : HY-114519
M.Wt: 304.34
Formula: C17H20O5
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 10180-86-6 :

Helenalin acetate, a natural NF-κB inhibitor, is a potent C/EBPβ inhibitor. Helenalin acetate has anti-inflammatory and anticancer activities[1]. In Vitro:Helenalin acetate (0.1-1 μM; for 7 days) inhibits the differentiation significantly in 3T3-L1 cells[1].
Helenalin acetate exerts anti-proliferative effects in acute myeloid leukemia cells but not in normal hematopoietic progenitor cells[1].
Helenalin acetate inhibits C/EBPβ by binding to the N-terminal part of C/EBPβ, thereby disrupting the cooperation of C/EBPβ with the co-activator p300. Helenalin acetate selectively inhibits only the full-length (liver-enriched activating protein* (LAP*)) isoform but not the slightly shorter (LAP) isoform[1].

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