Antiviral agent 52
CAS No. : 101784-44-5
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| Cat. No. : | HY-113860 |
| M.Wt: | 335.27 |
| Formula: | C18H20Cl2N2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Antiviral agent 52 (Compound 30) is a Chlorcyclizine (HY-112067) derivative that exhibits antiviral activity against hepatitic C virus (HCV) with an EC50 of 17 nM. Antiviral agent 52 reveals cytotoxicity in cell Huh7.5.1 with CC50 of 21.3 μM[1].
In Vivo:Antiviral agent 52 (10 mg/kg, i.p.) is preferentially in liver distributed without significant hepatotoxicity[1].
Pharmacokinetic Analysis of Antiviral agent 52 in CD-1 mouse[1]
| - | plasma | liver | liver/plasma |
| AUClast (μM·h) | 27.5 | 429 | 16 |
| AUCINF (μM·h) | 29.8 | 495 | 17 |
| T1/2 (h) | 6.7 | 8.5 | - |
| Tmax (h) | 0.083 | 0.083 | - |
| Cmax (h) | 5.28 | 57.0 | 11 |
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