EZ-482
CAS No. : 1016456-76-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $240 | In-stock |
| 25mg | $480 | In-stock |
| 50mg | $768 | In-stock |
| 100mg | $1230 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-103076 |
| M.Wt: | 498.94 |
| Formula: | C23H19ClN4O5S |
| Purity: | >98 % |
| Solubility: | DMSO : 83.33 mg/mL (ultrasonic) |
EZ-482, a novel ligand of apolipoprotein (apoE), binds to sites on apoE in the C-terminal domain with Kds of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer’s diseas[1].
IC50 & Target: Kd: 5-10 μM (apoE3 and apoE4)[1]
In Vitro: EZ-482 binds to sites on apoE in the C-terminal domain encompassing residues 229-243 and 258-265[1].
EZ-482 (0.5, 1, 5, 10 μM; 1 hour) blocks heparin binding in a concentration-dependent manner[1].
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