Gefapixant
CAS No. : 1015787-98-0
(Synonyms: MK-7264; AF-219)
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $140 | In-stock |
| 25mg | $280 | In-stock |
| 50mg | $420 | In-stock |
| 100mg | $630 | In-stock |
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| Cat. No. : | HY-101588 |
| M.Wt: | 353.40 |
| Formula: | C14H19N5O4S |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic;adjust pH to 5-6 with HCl) |
Gefapixant is an orally active and potent purinergic P2X3 receptor (P2X3R) antagonist, with IC50 values of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Gefapixant can be used for the research of chronic cough and knee osteoarthritis[1][2][3]. IC50 & Target:IC50: ~30 nM (recombinant hP2X3 homotrimers), 100-250 nM (hP2X2/3 heterotrimeric receptors)[1]. In Vitro: Gefapixant displays no inhibitory impact on any non-P2X3 subunit containing receptors (IC50 values >10,000 nM at recombinant homotrimeric hP2X1, hP2X2, hP2X4, rP2X5 and hP2X7 channels)[1]. In Vivo: Gefapixant (7d bid, orally) attenuates the weight bearing laterality with complete reversal of apparent hyperalgesia at the two higher doses in a rat model of knee osteoarthritis (14d following intra-articular administration of monoiodoacetate)[2].
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