Lanoconazole
CAS No. : 101530-10-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $85 | In-stock |
| 25mg | $160 | In-stock |
| 50mg | $256 | In-stock |
| 100mg | $410 | In-stock |
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| Cat. No. : | HY-14282 |
| M.Wt: | 319.83 |
| Formula: | C14H10ClN3S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi?in vitro?and?in vivo[1]. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis[1][2]. IC50 & Target: IC50: antifungal[1] In Vivo: Lanoconazole (treatment for ear; 0.3%-3%; 6 days) dose-dependently suppressesTPA-induced irritant dermatitis, suppresses the production of neutrophil chemotactic factors such as keratinocyte-derived chemokine and macrophage inflammatory protein-2, and inhibited neutrophil infiltration to the inflammation site[2].Lanoconazole (oral administration; 3, 10 or 30 mg/kg; once a day; 3 weeks) significantly inhibits?C. neoformans?compared with the saline control in normal mice. In addtion, it significantly reduces the growth of?C. neoformans?in the lungs and brains of MAIDS mice[3].
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