Sematilide
CAS No. : 101526-83-4
(Synonyms: CK-1752)
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| Cat. No. : | HY-101436 |
| M.Wt: | 313.42 |
| Formula: | C14H23N3O3S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Sematilide (CK-1752) is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM). Sematilide is a class III antiarrhythmic agent[1]. IC50 & Target: IC50: 25 μM (K+ current)[1] In Vitro: Application of 10, 30, 100 and 300 μM Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM)[1]. In Vivo: Sematilide (0.3-1.0 mg/kg, intravenously i.v.) is effective in a canine model of arrhythmia[2].
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