Sematilide (hydrochloride)
CAS No. : 101526-62-9
(Synonyms: CK-1752 (hydrochloride))
| Size | Price | Stock |
|---|---|---|
| 5mg | $70 | In-stock |
| 10mg | $112 | In-stock |
| 25mg | $230 | In-stock |
| 50mg | $380 | In-stock |
| 100mg | $600 | In-stock |
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| Cat. No. : | HY-101436A |
| M.Wt: | 349.88 |
| Formula: | C14H24ClN3O3S |
| Purity: | >98 % |
| Solubility: | H2O : 5 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : 1.67 mg/mL (ultrasonic;warming;heat to 60°C) |
Sematilide hydrochloride (CK-1752 hydrochloride) is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM). Sematilide is a class III antiarrhythmic agent[1]. IC50 & Target: IC50: 25 μM (K+ current)[1] In Vitro: Application of 10, 30, 100 and 300 μM Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM)[1]. In Vivo: Sematilide (0.3-1.0 mg/kg, intravenously i.v.) is effective in a canine model of arrhythmia[2].
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