β-CGRP, human


CAS No. : 101462-82-2

(Synonyms: Human β-CGRP; CGRP-II (Human))

101462-82-2
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Cat. No. : HY-P1548
M.Wt: 3793.41
Formula: C162H267N51O48S3
Purity: >98 %
Solubility: DMSO : ≥ 100 mg/mL
Introduction of 101462-82-2 :

β-CGRP, human (Human β-CGRP) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells[1]. IC50 & Target:IC50: 1 nM (CRLR/RAMP1, cell assay), 300 nM (CRLR/RAMP2, cell assay)[1] In Vitro: β-CGRP, human is one of calcitonin peptides, acts via complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM in both SK-N-MC and Swiss 3T3 cells express CRLR and RAMP1, and 130 nM and 300 nM in NG108-15 and HEK293T cells expressing CRLR and RAMP2[1]. CGRP is a potent vasodilator and also shows pro- and -anti-inflammatory activity[2].

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