CP-24879 (hydrochloride)
CAS No. : 10141-51-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $54 | In-stock |
| 5mg | $115 | In-stock |
| 10mg | $185 | In-stock |
| 25mg | $350 | In-stock |
| 50mg | $560 | In-stock |
| 100mg | $840 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-115319 |
| M.Wt: | 215.72 |
| Formula: | C11H18ClNO |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
CP-24879 (hydrochloride) is a potent, selective and combined delta5D/delta6D inhibitor. CP-24879 (hydrochloride) can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 (hydrochloride) exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes, and can be used for non-alcoholic steatohepatitis research[1][2].
IC50 & Target:IC50: 0.015 μM (delta6D in ABMC-7 cells), 0.56 μM (delta6D in Liver microsomes), 0.67 μM (delta5D in ABMC-7 cells), 3.4 μM (delta5D in ABMC-7 cells)[1]
In Vitro: CP-24879 (hydrochloride) (0-10 μM, 4 days) inhibits Δ6 + Δ5 desaturase activities in a concentration-dependent manner, with a concentration-dependent depletion of AA and decrease in LTC4 production[1].
CP-24879 (hydrochloride) (0-10 μM, 16 h) shows the inhibitory responses on oleic acid-induced triglyceride accumulation in hepatocytes[2].
CP-24879 (hydrochloride) (0-10 μM, 16 h) blocks LPS-induced expression of inflammatory cytokines in a concentration-dependent manner[2].
CP-24879 (hydrochloride) (0-2 μM, 4 h) inhibits desaturase activity and ameliorates ferroptosis[3].
In Vivo: CP-24879 (hydrochloride) (3 mg/kg, IP, three times a day, for 6 or 4 days) inhibits Δ6 + Δ5 desaturase activities in vivo, causing depletion of AA in the livers of chow-fed mice and preventing repletion of AA in the livers of EFAD mice[1].
CP-24879 (hydrochloride) (33 mg/kg, IV, once) is cleared quite rapidly and has a relatively short half-life[1].
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