Simvastatin hydroxy acid (sodium)
CAS No. : 101314-97-0
(Synonyms: Tenivastatin (sodium); Simvastatin Impurity A (sodium))
| Size | Price | Stock |
|---|---|---|
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| 5mg | $160 | In-stock |
| 10mg | $280 | In-stock |
| 25mg | $590 | In-stock |
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| Cat. No. : | HY-115292 |
| M.Wt: | 458.56 |
| Formula: | C25H39NaO6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Simvastatin hydroxy acid (Tenivastatin) sodium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin hydroxy acid sodium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin hydroxy acid sodium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1][2].
IC50 & Target:HMG-CoA reductase, Reactive oxygen species[1][2]
In Vitro: Simvastatin acid (0.1-20 μM; 24 h) significantly decreases ROS production between 8.9% and 43% in Indoxyl sulfate-treated hCM cells[2].
Simvastatin acid (0.1-20 μM; 24 h) alters the protein expression of OATP3A1 in hCMs and OATP3A1-expressing HEK293 cells[2].
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