Phenserine


CAS No. : 101246-66-6

(Synonyms: (-)-Eseroline phenylcarbamate; (-)-Phenserine)

101246-66-6
Price and Availability of CAS No. : 101246-66-6
Size Price Stock
5mg $150 In-stock
10mg $250 In-stock
50 mg Get quote
100 mg Get quote
We match the lowest price on market.

We offer a substantial discount on larger orders, please inquire via [email protected]

or Fax: (86)21-58955996

Inquiry for price and availability only. Please place your order via our email or fax.

Cat. No. : HY-103374
M.Wt: 337.42
Formula: C20H23N3O2
Purity: >98 %
Solubility: H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : 200 mg/mL (ultrasonic)
Introduction of 101246-66-6 :

Phenserine ((-)-Eseroline phenylcarbamate) is a derivative of Physostigmine (HY-N6608) and is a potent, noncompetitive, long-acting and selective AChE inhibitor. Phenserine reduces β-amyloid precursor protein (APP) and β-amyloid peptide (Aβ) formation. Phenserine improves cognitive performance and attenuates the progression of Alzheimer's disease[1][2][3]. IC50 & Target:AChE; β-amyloid precursor protein; β-amyloid peptide[1] In Vitro:Phenserine (1-25 μM; 48 hours; CHO APP751SW cells) treatment CHO APP751SW cell shows 18.6% reduction in cells treated with 10 μM of Phenserine, while 25 μM concentration of Phenserine reduces APP level by 51.4%[2]. In Vivo:Phenserine (1-4 mg/kg; intraperitoneal injection; for 4 days; male Fischer-344 rats) treatment improves learning when cholinergic function has been impaired in a spatial memory task[3].

Your information is safe with us.