Milnacipran (hydrochloride)
CAS No. : 101152-94-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $30 | In-stock |
| 10mg | $40 | In-stock |
| 25mg | $70 | In-stock |
| 50mg | $100 | In-stock |
| 100mg | $180 | In-stock |
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| Cat. No. : | HY-B0168A |
| M.Wt: | 282.81 |
| Formula: | C15H23ClN2O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 48 mg/mL;H2O : ≥ 100 mg/mL |
Milnacipran hydrochloride is an orally active Serotonin (HY-B1473A) and Norepinephrine (HY-13715) reuptake inhibitor. Milnacipran hydrochloride inhibits monoamine transporters, especially the norepinephrine transporter and the serotonin transporter (Ki values of 31 and 8.5 nM, respectively). Milnacipran hydrochloride inhibits pERK1/2 activation. Milnacipran hydrochloride has antidepressant, anxiolytic and analgesic properties. Milnacipran hydrochloride inhibits biting behavior in mice. Milnacipran hydrochloride can be used in the study of major depressive disorder, anxiety disorders, and neuropathic pain (e.g., fibromyalgia)[1][2][3][4][5][6][7][8].
IC50 & Target:norepinephrine transporter and the serotonin transporter (Ki values of 31 and 8.5 nM, respectively)
In Vitro:Milnacipran hydrochloride shows high affinity for 5-HT and NA transporters (Ki = 8.5 and 31 nM, respectively)[2].
Milnacipran (10-100 µM; 3 min) hydrochloride reduces the amplitude of NMDA (HY-17551)-induced currents in rat spinal lamina II neurons[5].
Milnacipran (100 µM; 10 min) hydrochloride suppresses NMDA (HY-17551)-induced pERK1/2 activation in superficial dorsal horn neurons[5].
In Vivo:Milnacipran (30-60 mg/kg; p.o.; single dose) hydrochloride shows anxiolytic effects in rats[2].
Milnacipran (30-120 mg/kg; p.o.) hydrochloride increases withdrawal threshold to tactile stimulation and latency to heat stimulation in a dose-dependent manner in rats with spinal nerve ligation (SNL)[4].
Milnacipran (0.01-0.1 µmol; intrathecal) hydrochloride suppresses hyperalgesia in a dose-dependent manner in mice with intrathecal NMDA-induced thermal hyperalgesia[5].
Milnacipran (3-30 mg/kg; i.p.) hydrochloride suppresses impulsive, aggressive, and depressive-like behaviors in male C57BL/6N mice[6].
Milnacipran (20-60 mg/kg; i.p.) hydrochloride suppresses food intake in fasted male C57BL/6J and Ay mice, increases hypothalamic POMC and CART mRNA levels, and does not elevate plasma corticosterone or blood glucose[7].
Milnacipran (0.1-10 μg/site; intrathecal) hydrochloride inhibits Serotonin-induced biting behavior in male ICR mice[8].
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