GSK369796 Dihydrochloride
CAS No. : 1010411-21-8
| Size | Price | Stock |
|---|---|---|
| 2mg | $132 | In-stock |
| 5mg | $192 | In-stock |
| 10mg | $264 | In-stock |
| 50mg | $792 | In-stock |
| 100mg | $1320 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12082A |
| M.Wt: | 428.78 |
| Formula: | C20H24Cl3N3O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 50 mg/mL (ultrasonic) |
GSK369796 Dihydrochloride is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization with an IC50 of 7.5 μM. IC50 & Target: IC50: 7.5 μM (hERG potassium ion channel)[1] In Vitro: In vitro, GSK369796 Dihydrochloride can inhibit the growth of Plasmodium falciparum strains 3D7c, HB3c and K1d, with IC50s of 11.2±2.2, 12.6±5.3 and 13.2±3.2 nM, respectively. Protein binding is higher for GSK369796 Dihydrochloride (compound 4) compare to desethyl amodiaquine in the mouse (93 vs 74%) but similar in human (88 vs 86%). GSK369796 Dihydrochloride can also inhibit hERG potassium ion channel repolarization with an IC50 of 7.5±0.8 μM[1]. In Vivo: In vivo, GSK369796 Dihydrochloride can inhibit the growth of Plasmodium berghei ANKA with ED50 and ED90 of 2.8 and 4.7 mg/kg, respectively[1].
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