Artemisitene


CAS No. : 101020-89-7

101020-89-7
Price and Availability of CAS No. : 101020-89-7
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1mg $119 In-stock
5mg $250 In-stock
10mg $420 In-stock
25mg $750 In-stock
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Cat. No. : HY-122550
M.Wt: 280.32
Formula: C15H20O5
Purity: >98 %
Solubility: DMSO : ≥ 100 mg/mL
Introduction of 101020-89-7 :

Artemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability[1][2]. In Vitro: Artemisitene selectively induces DNA double-stranded breaks (DSBs) and apoptosis in various human cancer cells by suppressing the expression of topoisomerases in human cancer cells. Artemisitene selectively destabilizes c-Myc in human cancer cells by promoting the ubiquitination of c-Myc through the specific induction of the c-Myc E3 ligase NEDD4[2]. In Vivo: In Nrf2 wild-type mice, systemic administration of Artemisitene (5-10 mg/kg; i.p.) strongly inhibits bleomycin-induced lung damage[1].

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