Pyridostigmine (bromide)
CAS No. : 101-26-8
| Size | Price | Stock |
|---|---|---|
| 500mg | $55 | In-stock |
| 1g | $98 | In-stock |
| 5g | $200 | In-stock |
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| Cat. No. : | HY-B0207A |
| M.Wt: | 261.12 |
| Formula: | C9H13BrN2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic);H2O : 8.8 mg/mL (ultrasonic;warming) |
Pyridostigmine bromide is an orally active cholinesterase (ChE) inhibitor that can be used in cardiovascular disease research[1][2][3][4][5]. In Vitro: Pyridostigmine bromide (10-80 ng/mL, 3-72 hours) at low concentrations (10-40 ng/mL) enhances SH-SY5Y cell activity and mitochondrial activity, while at high concentration (80 ng/mL) it inhibits cell viability[5]. Pyridostigmine bromide (60-80 ng/mL, 72 hours) promotes the accumulation of SH-SY5Y cells in the S phase[5]. Pyridostigmine bromide (40-80 ng/mL, 24 hours) upregulates the expression of the telomerase gene, p53 gene, and DNMT1 gene in SH-SY5Y cells[5]. In Vivo: Pyridostigmine bromide (1 or 3 mg/kg, s.c., once daily for 7 days) can reduce acetylcholinesterase activity in the blood of C57BL/6J mice[3]. Pyridostigmine bromide (30 mg/kg, p.o., once daily for one month) improves myocardial changes and reduces inflammatory responses in a Trypanosoma cruzi infection-induced chronic Chagas cardiomyopathy C57BL/6J mouse model[4].
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